The best way to ensure that your information is safe is by encrypting it. PGP Desktop lets you do just that by easily creating and managing keys.
Despite a lengthy installation, needed so that you can create your own pass phrase, choose your email and enter other user settings, PGP Desktop is easy to work with, even if it may be best suited for the enterprise user.
Create a new key is just a case of dragging and dropping the files you want to encrypt. The interface then display all of your keys, which you can manage easily.
PGP allows you to save files in encrypted zip files and even store them on an encrypted disk. The developers have not omitted the fact that files are mostly exchanged online and provides a safe solution for that too. You'll also notice that it keeps a log of any activity, so you can verify what has been encrypted.
If you work constantly with sensitive material, then PGP Desktop should make your life much easier, encrypting any files quickly.
- Addressed an issue that would cause PGP Desktop for Mac OS X to prompt for user's passphrase multiple times.  Resolved an issue where un-instrumenting a disk drive would not restore the original boot.efi file on Mac OS X systems.  Resolved an issue where upgrading to Mac OS X 10.6.5 could cause the system to fail to boot into PGP BootGuard.  Addressed an issue in PGP Desktop for Mac OS X that could cause enrollment failure.  Enhanced the ability of PGP Desktop for Mac OS X when the PGP Universal Server authentication cookie is missing in the keychain.